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知名专家指出:情绪益生菌PS128能改善孤独症违抗行为与多动症状!

新闻报道:知名专家指出:情绪益生菌PS128能改善孤独症违抗行为与多动症状!


125日,浙江省神经科学学会孤独症专业委员会召开第一届换届大会,同期举办“孤独症多学科研究与前沿干预技术培训班”。本次培训班汇聚孤独症相关领域的专家学者、残联工作者、医护人员、康复人员、教育工作者及相关机构代表及孤独症专业委员会成员,通过专题讲座、案例研讨与技术培训等多种形式,围绕孤独症的神经机制研究及临床干预技术等前沿议题展开深入交流,旨在搭建高水平学术交流平台,促进基础研究与临床实践深度融合,提升从业人员专业素养。

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会议当天由中南大学湘雅二医院欧建君主任为现场参会人员带来了《孤独症的诊断与治疗现状及发展》报告,系统梳理了当前孤独症的诊疗进展,并重点分享了肠道菌群调节物可干预孤独症等神经障碍疾病的前沿发现。欧主任指出,特定益生菌如植物乳杆菌PS128,能通过肠脑轴影响中枢神经系统,从而能在一定程度上改善孤独症儿童的对立、违抗行为及注意缺陷和多动症状。

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植物乳杆菌PS128是何方神圣?又为何能干预孤独症呢?据了解,植物乳杆菌PS128(情绪益生菌PS128)是台湾阳明大学蔡英杰教授研究团队从台湾传统发酵食品福菜中分离得到的功能性菌株。研究团队在经过细胞实验(抗炎、免疫调节等)和动物模型(肠炎症模型、肥胖模型、IBS疼痛模型等)、动物行为实验(强迫游泳实验、旷野实验、糖水兴趣实验)等无数次科学实验中,惊喜发现植物乳杆菌PS128能够有效平衡大脑神经递质多巴胺和血清素水平,降低压力激素皮质酮,增加脑源性神经营养因子BDNF及神经生长因子NGF含量,在精神心理方面展现出优越的应用潜力。

基于前期研究成果,蔡英杰教授团队在台湾地区招募了72名被诊断为孤独症的男孩(7–15岁),开展了亚洲首次针对儿童孤独症的情绪益生菌辅助治疗的临床实验。研究团队将参与儿童随机分为两组:一组服用植物乳杆菌 PS128,另一组则服用安慰剂胶囊作为对照,进行为期四周的临床研究。实验前后,通过医师问诊和家长填写评估问卷,对孤独症、ADHD、儿童问题行为等相关症状的变化进行系统评估。研究结果显示,7–15 岁孤独症儿童在连续 28 天补充PS128 后,破坏性行为、规则扰乱性行为显著减少,多动和冲动行为得到明显改善,显示出 PS128 在干预孤独症儿童行为方面的优异表现。

截至目前,围绕植物乳杆菌PS128(情绪益生菌PS128)开展孤独症干预的研究已取得多项成果,并在权威学术期刊上发表多篇论文。随着相关循证研究的不断累积,以植物乳杆菌PS128(情绪益生菌PS128)为代表的功能性益生菌,将可望为孤独症干预提供更加科学、丰富的实践路径,为更多的孤独症儿童和家庭带来希望的曙光。

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